FHTX
Foghorn Therapeutics Inc.4.4800
+0.1100+2.52%
Dec 16, 4:00:00 PM EST
Earnings Call Transcripts
This Quarter (Q4 '25)
No earnings call transcript available yet
Last Quarter (Q3 '25)
No earnings call transcript available
Key Stats
Market Cap
253.35MP/E (TTM)
-Basic EPS (TTM)
-1.14Dividend Yield
0%Recent Filings
8-K
8-K
Foghorn advances chromatin oncology pipeline
Foghorn Therapeutics unveiled its November 2025 investor presentation, spotlighting the Phase 1 trial of FHD-909, a selective SMARCA2 inhibitor partnered with Lilly for SMARCA4-mutant cancers like NSCLC, where mutations hit up to 10% of cases and worsen outcomes. Preclinical degraders targeting CBP, EP300, and ARID1B show potent anti-tumor activity in models of breast cancer, heme malignancies, and solid tumors, with IND-ready milestones in 2026. Backed by $180.3 million in cash through 2028, the pipeline exploits chromatin biology for precision oncology. Risks loom in clinical translation.
8-K
Degrader pipeline advances
Foghorn Therapeutics unveiled preclinical advances in its degrader programs on October 30, 2025, targeting ARID1B for ARID1A-mutant solid tumors, CBP for EP300-mutant cancers and ER+ breast cancer, and EP300 for hematological malignancies like multiple myeloma. Selective degraders showed robust anti-tumor activity without key toxicities such as thrombocytopenia, while advancing toward in vivo proof-of-concept and IND readiness in 2026. These updates highlight Foghorn's platform edge in chromatin biology. Yet risks from clinical uncertainties persist.
8-K
Foghorn unveils pipeline progress
Foghorn Therapeutics released its September 2025 investor presentation, spotlighting the Phase 1 trial of FHD-909, a selective SMARCA2 inhibitor partnered with Lilly for SMARCA4-mutant cancers like NSCLC, where mutations hit up to 10% of cases and worsen outcomes. Preclinical data show tumor regressions in models, especially combined with KRAS inhibitors or chemo, while degraders for CBP, EP300, and ARID1B advance toward 2026 INDs. Cash stands at $198.7 million, funding into 2028. Risks lurk in clinical uncertainties.
8-K
Foghorn Q2 pipeline advances
Foghorn Therapeutics reported Q2 2025 results, highlighting strong pipeline momentum with FHD-909's Phase 1 trial in SMARCA4-mutated NSCLC enrolling on track since October 2024, backed by Lilly collaboration. Preclinical data showed FHD-909 synergizing with pembrolizumab and KRAS inhibitors for enhanced anti-tumor activity. Selective CBP degrader advances to IND in 2026; EP300 and ARID1B updates due Q4 2025. Cash at $198.7 million funds operations into 2028, while net loss narrowed to $17.9 million from $23.0 million year-over-year. Pipeline risks hinge on clinical trial outcomes.
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