SION
Sionna Therapeutics, Inc.42.89
+0.13+0.3%
Dec 16, 4:00:00 PM EST
Earnings Call Transcripts
This Quarter (Q1 '26)
No earnings call transcript available yet
Last Quarter (Q4 '25)
No earnings call transcript available
Key Stats
Market Cap
1.91BP/E (TTM)
-Basic EPS (TTM)
-1.80Dividend Yield
0%Recent Filings
8-K
Sionna's 2025 results, cash runway
Sionna Therapeutics reported full-year 2025 net loss of $75.3 million, up from $61.7 million in 2024, driven by ramped R&D at $60.3 million and G&A at $28.7 million. Cash stands at $310.3 million, funding operations into 2028. Phase 2a SION-719 trial and Phase 1 SION-451 combo trial hit mid-2026 topline data. Cash fuels the pipeline.
10-K
FY2025 results
Sionna Therapeutics posted FY2025 net loss of $75.3M, up 22% y/y from $61.7M, on ramped R&D to $60.3M (vs $57.3M) funding Phase 1 readouts for NBD1 stabilizers SION-719/SION-451 and Phase 2a PreciSION CF initiation. Q4 burn accelerated with clinical momentum; cash hit $310.3M post-$200M IPO, funding ops into 2028. No revenue; IPO fueled $206M financing inflow. Pipeline advanced sans topline sales. Clinical trials may fail to show efficacy.
8-K
Launches CF trials, bolsters cash
Sionna Therapeutics initiated PreciSION CF Phase 2a trial of SION-719 as CF add-on to standard of care and Phase 1 dual combo trial of SION-451, both with topline data mid-2026. R&D expenses dropped to $16M from $24.6M year-over-year, driving net loss to $20.3M. Cash hit $325M, funding ops into 2028. Pipeline accelerates.
10-Q
Q3 FY2025 results
Sionna narrowed its Q3 operating loss to $23.8M from $28.0M y/y, as R&D expenses dropped 35% to $16.0M—absent last year's $13.6M IPR&D hit from the AbbVie deal—while G&A rose to $7.8M on public company costs and hiring; nine-month net loss widened to $54.8M from $45.8M y/y amid pipeline ramp. Interest income boosted other income 39% y/y to $3.5M. Cash and marketable securities swelled to $325.0M post-February IPO, funding ops into 2028. Vertex holds dominant CF market share.
8-K
Positive Phase 1 CF drug data
Sionna Therapeutics reported positive Phase 1 data for NBD1 stabilizers SION-719 and SION-451, showing good tolerability and strong pharmacokinetics in over 200 healthy volunteers. The company plans Phase 2a initiation for SION-719 in CF patients this half, with topline results mid-2026, while advancing SION-451 combos. Cash stands at $337.3 million, funding ops into 2028. Net loss hit $18.1 million amid rising R&D costs. Progress fuels CF therapy hopes.
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